Microsoft announced a bug for the RTM version for vista which caused a 3rd Party applications to not run properly.
Microsoft has released an update to fix this problem.

All other vista users – you guys don't need to worry as all other versions has been released after the RTM bug has been fixed, so 8hands (and all other applications) should work fine.

To download the fix:

http://www.iexbeta.com/wiki/index.php/Windows_Vista_RTM_Bug_List#3rd_Par...